CytopointThis treatment applies to the following species:
Canine Atopic Dermatitis Immunotherapeutic
For Use in Dogs Only
Cytopoint™ aids in the reduction of clinical signs associated with atopic dermatitis in dogs.
Cytopoint™ is a ready-to-use, sterile liquid containing a caninized monoclonal antibody (mAb) against interleukin-31 (IL-31). IL-31 has been shown to induce pruritus in dogs in laboratory studies.
Cytopoint™ remains in circulation for several weeks. It exerts a therapeutic effect by binding to and neutralizing soluble IL-31, thus inhibiting pruritus and reducing skin lesions. Like other naturally-occurring antibodies and antibody-antigen complexes, elimination is via normal protein degradation pathways.
SAFETY: A field safety study has demonstrated that Cytopoint™ is well tolerated in dogs after subcutaneous injection. Adverse events occurred at a similar frequency between treated and placebo groups in a study of 245 canine patients presented to veterinary hospitals and diagnosed with atopic dermatitis. In this study, dogs were administered Cytopoint™ (1.0-3.3 mg/kg body weight) or placebo by the subcutaneous route on Days 0 and 28. Signs of patient discomfort on administration and adverse events occurred at a similar frequency between treatment groups. In addition, there was no clinically important difference in clinical pathology changes between groups following either dose. A wide variety of concomitant medications were safely used, including parasiticides, antibiotics, antifungals, corticosteroids, vaccines, immunotherapy, antihistamines and other antipruritics, such as oclacitinib and cyclosporine.
Cytopoint™ has also been demonstrated to be well-tolerated in dogs in a laboratory safety study in which 7 consecutive monthly subcutaneous injections were administered at doses of 3.3 mg/kg or 10 mg/kg body weight (12 dogs per group).
Single-use 1 mL vials in 4 concentrations
10 mg, 20 mg, 30 mg or 40 mg/vial
Cytopoint is available in both 5-vial and 10-vial presentation sizes
0.09 mL/lb drawn from ONE 10 mg vial.
Draw full volume from ONE 1 mL vial as indicated.
Requires full volume of TWO OR MORE 1 mL vial as indicated.
Draw the entire dose (or volume) from each vial into 1 syringe and administer as a single injection.
PLEASE ENTER WEIGHT TO SEE VIALS NEEDED
PLEASE ENTER A VALID WEIGHT UP TO 200 LB Dosing instructions per US approved Prescribing Information. The dose varies depending on country of licensure.
Cytopoint for dogs! How Cytopoint works with Dr. Dan
Cytopoint® is available in 1-mL vials in four concentrations (10, 20, 30 or 40 mg). Administer Cytopoint® at a minimum dose of 0.9 mg/lb (2 mg/kg) body weight. For convenience, the dosing tables below may be used as a guideline. Repeat administration every 4-8 weeks as needed in individual patients.