How do they test for taurine deficiency in dogs? A Step-by-Step Guide

Here is more information on the Taurine Deficiency issue:

The U.S. Food and Drug Administration (FDA) is alerting pet owners and veterinary professionals about reports of canine Dilated Cardiomyopathy (DCM) in dogs eating certain pet foods containing peas, lentils, other legume seeds, or potatoes as main ingredients. These reports are unusual because DCM is occurring in breeds not typically genetically prone to the disease. The FDA’s Center for Veterinary Medicine and the Veterinary Laboratory Investigation and Response Network, a collaboration of government and veterinary diagnostic laboratories, are investigating this potential association.

Canine DCM is a disease of a dog’s heart muscle and results in an enlarged heart. As the heart and its chambers become dilated, it becomes harder for the heart to pump, and heart valves may leak, leading to a buildup of fluids in the chest and abdomen. DCM often results in congestive heart failure. Heart function may improve in cases that are not linked to genetics with appropriate veterinary treatment and dietary modification, if caught early.The underlying cause of DCM is not truly known, but is thought to have a genetic component. Breeds that are typically more frequently affected by DCM include large and giant breed dogs, such as Great Danes, Boxers, Newfoundlands, Irish Wolfhounds, Saint Bernards and Doberman Pinschers. It is less common in small and medium breed dogs, except American and English Cocker Spaniels. However, the cases that have been reported to the FDA have included Golden and Labrador Retrievers, Whippets, a Shih Tzu, a Bulldog and Miniature Schnauzers, as well as mixed breeds.

Diets in cases reported to the FDA frequently list potatoes or multiple legumes such as peas, lentils, other “pulses” (seeds of legumes), and their protein, starch and fiber derivatives early in the ingredient list, indicating that they are main ingredients. Early reports from the veterinary cardiology community indicate that the dogs consistently ate these foods as their primary source of nutrition for time periods ranging from months to years. High levels of legumes or potatoes appear to be more common in diets labeled as “grain-free,” but it is not yet known how these ingredients are linked to cases of DCM. Changes in diet, especially for dogs with DCM, should be made in consultation with a licensed veterinarian.

In the reports the FDA has received, some of the dogs showed signs of heart disease, including decreased energy, cough, difficulty breathing and episodes of collapse. Medical records for four atypical DCM cases, three Golden Retrievers and one Labrador Retriever, show that these dogs had low whole blood levels of the amino acid taurine. Taurine deficiency is well-documented as potentially leading to DCM. The Labrador Retriever with low whole blood taurine levels is recovering with veterinary treatment, including taurine supplementation, and a diet change. Four other cases of DCM in atypical dog breeds, a Miniature Schnauzer, Shih Tzu and two Labrador Retrievers, had normal blood taurine levels. The FDA continues to work with board certified veterinary cardiologists and veterinary nutritionists to better understand the clinical presentation of these dogs. The agency has also been in contact with pet food manufacturers to discuss these reports and to help further the investigation.

If your pet is on a grain free diet, NOT prescribed specifically by a doctor, we recommend that you change their diet to one that is not based on peas, lentils, garbanzo beans, potatoes and sweet potatoes as soon as possible. At this time, there is no one manufacturer or pet food being singled out by the FDA. Many diets are implicated. In time, we will know more about the problem. It appears that the lentil, pea and potato diets are blocking your dog’s ability to utilize taurine, an amino acid important for adequate taurine metabolism to protect your dog’s heart. Diets in cases reported to the FDA frequently list potatoes or multiple legumes such as peas, lentils, (seeds of legumes), and their protein, starch and fiber derivatives early in the ingredient list, indicating that they are main ingredients. The affected dogs consistently ate these foods as their primary source of nutrition for time periods ranging from months to years. High levels of legumes or potatoes appear to be more common in diets labeled as “grain-free,” but it is not yet known how these ingredients are linked to cases of DCM.

Please select a non-grain free diet. These will have corn, rice, oatmeal, barley, beet pulp, or other carbohydrates in them. These are not inferior or bad diets. We recommend Hills Science Diet, Royal Canin, and Purina food avoiding their grain free or limited antigen diets. We are also familiar with Fromm and American Premium Natural diets that are made in Wisconsin. Avoid anything that says grain-free, peas, lentils, beans, potatoes and sweet potatoes in the first 10 ingredients on the list. Also look at items likes peas listed in more than 1 form in the diet – like peas and pea flour – in this way they can put more peas in the diet and hide the fact they are heavily pea or lentil based. Be sure to read the back of the bag or website. Do not count on the label on the front of the bag to have enough information on it to rely on for your decision. Call the 800 number the company has on their website or package for additional assistance.

If you are still concerned, you can purchase taurine over the counter from us or in local pet stores – the dose is 250 to 1000 mg 2 times a day based on the size of the dog. Dark meat cooked chicken is also a good way to add taurine to the diet.

The symptoms or signs of heart disease, including decreased energy, cough, difficulty breathing and episodes of collapse.

Please discuss this with your veterinarian so we can be certain your pet is on the best possible diet for him or her. We recommend feeding Hill’s Science Diet/Prescription Diet, Royal Canin, and Purina. The Veterinary Prescription Diets are safe and you should not change from these without your veterinarian’s specific recommendation.

The FDA encourages pet owners and veterinary professionals to report cases of DCM in dogs suspected of having a link to diet by using the electronic Safety Reporting Portal or calling their state’s FDA Consumer Complaint Coordinators. Please contact the FDA and follow the directions in the “How to Report a Pet Food Complaint” section near the bottom.

Shipping Samples:

If shipping the same day: plasma, whole blood or urine samples can be held in the refrigerator until shipped. Please ship on ice.

If holding the sample 24 hours or longer: plasma, whole blood, or urine samples should be frozen (-18ºC or 0ºF) until shipped. Please ship on ice.

Please ship samples overnight. You are able to use the carrier of your choice (FedEx, UPS, USPS). We do not receive samples on weekends or University Holidays, so please only ship Monday-Wednesday for USPS or Monday-Thurs for FedEx and UPS.

Our address is:

Amino Acid Laboratory University of California, Davis 1089 Veterinary Medicine Drive 1020 Vet Med 3B Davis, CA 95616

Shipping Tips:

  • Glass tubes will easily break in transit, please pad them appropriately.
  • Tube lids can come off in transit, please fasten them securely.
  • Submission forms are easily soaked due to leaky/wet ice packs, please fully enclose in a plastic bag
  • Complete amino acid analysis results (for plasma and urine) will be available within 14 working days. Sample numbers larger than 60 may require additional time.

    Taurine analysis results (plasma, whole blood, urine) will be available within 10 working days.

    Samples needing hydrolysis or digestion (food, body tissue, or other solid samples) will require 3 additional days for any test.

    Taurine Deficiency and Dilated Cardiomyopathy in Dogs

    Taurine deficiency is one cause of a heart condition called dilated cardiomyopathy (DCM), where the heart muscle thins and the chambers become enlarged. This is true for cats, and may now also be true for dogs.

    Recently, studies have found a connection between DCM and these breeds of dogs:

    While research is ongoing, there are theories that the onset of DCM is related to the diet, specifically, grain-free diets. However, the question remains whether the DCM occurs due to an overall lack of taurine in the dog food or other dietary factors that cause problems with taurine digestion, absorption, metabolism, and/or excretion.

    Taurine deficient cardiomyopathy and why I switched dog foods

    Taurine deficiency in dogs happens when there is a lack of the amino acid taurine, which is important for dogs’ health, in the body.

    Usually dogs’s bodies synthesize taurine on their own, which is why it’s not normally essential to add it to their food. Cats, on the other hand, do need to take in taurine from their food sources. However, some dogs may need taurine added to their diets if they have a deficiency related to medical conditions.

    Taurine is especially concentrated in the heart muscles, eye retinas, and brain. It’s important for keeping those organs healthy, though its exact function isn’t well understood. A taurine deficiency can cause an enlarged heart, which leads to serious health problems.

    If you see the signs of a taurine deficiency in your dog, then you must talk to your veterinarian. They will help you form a diet that will treat the condition.

    Here’s what you should know about the symptoms, causes, and treatments for taurine deficiency in dogs.