Does Simparica trio make dogs sick? Here’s What to Expect

How Much Does Simparica Trio Cost?

The cost of Simparica Trio generally ranges from $22–30 per dose depending on the tablet size, number of doses, and source of purchase. It comes in a pack of six or 12, but veterinarians typically sell individual doses for growing puppies. The product can be purchased directly from your vet, from your vets online pharmacy, or through an external online pharmacy with a valid prescription.

Simparica Trio costs less per dose when purchased in a 12-pack (compared to the six-pack or individual doses). Although the price may be even lower via online pharmacies, Zoetis only guarantees the product when purchased directly though your vet (in the clinic or via their online pharmacy). The company will not cover any products purchased through sites like Chewy or 1-800-Pet-Meds because they cannot be tracked to ensure theyre legitimate and properly stored/handled (and due to the companys stance on product diversion).

Simparica Trio comes with a customer satisfaction guarantee: Zoetis will cover some or all vet expenses should your dog develop heartworm disease, Lyme disease, a flea infestation, hookworms, or roundworms. However, your dog must have a history of negative test results for these diseases. This is just another reason to follow your vets recommendations for annual physical exams and tests.

What Is Simparica Trio for Dogs?

Simparica Trio is the brand name of a chewable tablet that protects dogs from heartworm disease, fleas, five species of ticks, and two types of intestinal parasites. Manufactured by Zoetis, Simparica Trio contains three drugs: sarolaner, moxidectin, and pyrantel pamoate. Its only available with a prescription from your veterinarian, so you cannot get it over-the-counter.

Sarolaner is an acaricide (kills ticks and mites) and insecticide (kills fleas) belonging to the isoxazoline class of drugs. It works by creating uncontrolled neuromuscular activity leading to death in fleas as well as some ticks and mites. Sarolaner is effective against the following tick species:

  • Gulf Coast tick
  • Brown dog tick
  • Deer tick/black-legged tick (common carriers of Lyme disease)
  • American dog tick
  • Lone Star tick
  • Moxidectin is an antiparasitic drug in the macrocyclic lactone class. It kills heartworm larvae by causing paralysis that leads to the death of the parasite.

    Pyrantel pamoate is a nematocide (kills some worms) belonging to the tetrahydropyrimidine class. It causes paralysis that leads to death of hookworms and roundworms.

    Simparica Trio is just one of many parasite prevention products on the market for dogs. Its unique because it kills more types of parasites than any other combination product available to date. However, some dog parents prefer to use separate products. One common alternative is to give Heartgard for heartworms and intestinal parasites along with Bravecto to prevent fleas and ticks, but there are other choices out there. Your veterinarian is the best source of information and will help you choose the right product for your dog and your budget.

    What Are Potential Simparica Trio Side Effects in Dogs?

    Side effects are uncommon, but may occur in some cases. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. My personal dog has had no issues at all, and shes been on it for nearly two years. Other signs may include:

  • Lethargy
  • Loss of appetite
  • Increased urination and/or drinking
  • Hyperactivity
  • Contact your veterinarian if you notice these or other signs of illness after giving Simparica Trio to your dog.

    [Warning] Flea and Tick Product Side Effects