Does Zofran Make You Sleepy

Zofran (ondansetron) is used to relieve nausea and vomiting commonly associated with cancer treatments like chemotherapy and radiation. It can also be used to prevent and treat post-surgical nausea and vomiting. Common side effects associated with Zofran include headache, drowsiness, constipation and the chills.

Tell the healthcare provider about all medical conditions

The first step in avoiding serious side effects is to make sure the prescribing healthcare professional knows about your medical conditions and medical history. For ondansetron, side effects are more likely in people with the following medical conditions:

  • Heart disease
  • Heart rhythm abnormalities
  • Slow heartbeats
  • Electrolyte imbalance
  • Any history or family history of QT prolongation
  • Any intestinal blockage
  • Liver disease
  • Any history of allergies to ondansetron, granisetron, palonosetron, or dolasetron
  • While there is no certainty about the risks, make sure to tell the healthcare provider about pregnancy, breastfeeding, or any plans to get pregnant or breastfeed.

    How to avoid Zofran side effects

    For the most part, Zofran’s side effects are minor—usually a headache, drowsiness, and constipation. A few tips, however, can reduce both the incidence and severity of side effects.

    Take Zofran tablets exactly as instructed. The typical dose is 8–16 mg in one to eight doses taken over a few days. Do not skip a dose or stop taking the medicine early. The doctor may give special instructions if you vomit after taking Zofran tablets, so follow these instructions carefully.

    Contact a healthcare provider if vomiting continues

    If vomiting continues, contact a healthcare provider. An additional dose may be prescribed or the healthcare provider may switch to another medication.


    Does Zofran cause tiredness?

    Headache, lightheadedness, dizziness, drowsiness, tiredness, or constipation may occur. If these effects persist or worsen, notify your doctor promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.

    Is Zofran a sedating?

    Side effects of ondansetron and promethazine that are similar include drowsiness and sedation, constipation, and dizziness.

    Does Zofran make you sleepy like Phenergan?

    Zofran is an antiemetic (anti-nausea and vomiting) and selective 5-HT3 receptor antagonist and Phenergan is an antihistamine. Side effects of Zofran and Phenergan that are similar include dizziness, drowsiness, constipation, and blurred vision.

    Does Zofran make you sleepy like Dramamine?

    Ondansetron is a serotonin-3 (5-HT3) receptor antagonist, and Dramamine is an antihistamine. Side effects of ondansetron and Dramamine that are similar include drowsiness and constipation.