Ondansetron is an anti-sickness medicine, also known as an antiemetic. It is a serotonin receptor antagonist. It is prescribed to stop you from feeling sick (nauseated). It works by blocking the effect of a naturally produced chemical in your body, called serotonin. Serotonin is also referred to as 5HT3.
Chemotherapy, radiotherapy and surgery can all cause the release of an increased amount of serotonin in your body. There are tiny areas in your small intestine and brain called 5HT3 receptors. Serotonin acts on these receptors and causes you to feel sick. Ondansetron works by blocking serotonin from acting on the receptors, and this stops you from feeling sick or being sick (vomiting).
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking ondansetron it is important that your doctor knows:
What drugs and food should I avoid while taking Ondansetron (Zofran)?
Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
How to avoid Zofran side effects
For the most part, Zofran’s side effects are minor—usually a headache, drowsiness, and constipation. A few tips, however, can reduce both the incidence and severity of side effects.
Take Zofran tablets exactly as instructed. The typical dose is 8–16 mg in one to eight doses taken over a few days. Do not skip a dose or stop taking the medicine early. The doctor may give special instructions if you vomit after taking Zofran tablets, so follow these instructions carefully.
Tell the healthcare provider about all medications
Drug interactions between ondansetron and other medications can also cause problems. The healthcare provider particularly needs to know if you are taking any of the following medications:
Do not take other prescriptions or over-the-counter medicines until checking in with a doctor or other healthcare provider.
How long does it take for Zofran to come out of your system?
Why do I still feel nauseous after taking Zofran?
Can Zofran make you groggy?
Will Zofran stop vomiting?