How Long Does It Take For Zofran To Wear Off

Ondansetron is an anti-sickness medicine, also known as an antiemetic. It is a serotonin receptor antagonist. It is prescribed to stop you from feeling sick (nauseated). It works by blocking the effect of a naturally produced chemical in your body, called serotonin. Serotonin is also referred to as 5HT3.

Chemotherapy, radiotherapy and surgery can all cause the release of an increased amount of serotonin in your body. There are tiny areas in your small intestine and brain called 5HT3 receptors. Serotonin acts on these receptors and causes you to feel sick. Ondansetron works by blocking serotonin from acting on the receptors, and this stops you from feeling sick or being sick (vomiting).

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking ondansetron it is important that your doctor knows:

The effects of Zofran (ondansetron) can last anywhere between 8 to 12 hours.

What drugs and food should I avoid while taking Ondansetron (Zofran)?

Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

How to avoid Zofran side effects

For the most part, Zofran’s side effects are minor—usually a headache, drowsiness, and constipation. A few tips, however, can reduce both the incidence and severity of side effects.

Take Zofran tablets exactly as instructed. The typical dose is 8–16 mg in one to eight doses taken over a few days. Do not skip a dose or stop taking the medicine early. The doctor may give special instructions if you vomit after taking Zofran tablets, so follow these instructions carefully.

Tell the healthcare provider about all medications

Drug interactions between ondansetron and other medications can also cause problems. The healthcare provider particularly needs to know if you are taking any of the following medications:

  • Apokyn (apomorphine)
  • Drugs that treat heart rhythm
  • Medicines that treat depression, anxiety, psychosis, bipolar disorder, or other psychiatric disorders
  • Migraine medications, especially triptans
  • Do not take other prescriptions or over-the-counter medicines until checking in with a doctor or other healthcare provider.


    How long does it take for Zofran to come out of your system?

    Zofran has a half-life of three to four hours in healthy adults, but this may be increased to six to eight hours in older adults. This means it takes the body three to four hours to eliminate half a dose of Zofran from the body, so the entire dose should be eliminated in 15 to 20 hours.

    Why do I still feel nauseous after taking Zofran?

    While Zofran can offer relief to some patients who can’t eat or struggle with chronic nausea, it can also create severe side effects. These side effects include. These side effects could be a warning of a severe reaction or intolerance to the drug. People suffering them should advise their doctor as soon as possible.

    Can Zofran make you groggy?

    Zofran may cause headaches, drowsiness, constipation and other mild side effects. In rare cases, the anti-nausea medication can cause erratic heartbeats and high serotonin levels, which may be life-threatening.

    Will Zofran stop vomiting?

    This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body’s natural substances (serotonin) that causes vomiting.