How much melatonin is safe for a dog? Let’s Explore

Melatonin for Stress, Anxiety, and Phobias in Dogs

Melatonin may be helpful for dogs who regularly experience anxiety, stress, phobias, or signs of cognitive dysfunction .

Many dogs experience anxiety that may be triggered by fear of a potential threat, separation from their family, or changes in their environment or routine. Anxiety and sleep problems Trusted Source National Library of Medicine, Biotech Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. pubmed.ncbi.nlm.nih.gov can also be a sign of cognitive problems in older dogs.

Anxiety sometimes occurs as a phobia, which describes a sudden and intense response to a trigger, such as loud noises from a vacuum cleaner, fireworks, or thunder. Because dogs cannot say when they are anxious or afraid, they may display their anxiety through a wide range of behaviors, including:

  • Chewing, scratching, or other destructive behavior
  • Shaking or shivering
  • Barking, howling, or crying
  • Going to the bathroom in the house
  • Excessive salivating
  • Pacing or having difficulty settling down
  • Refusing to eat
  • These and other behavioral challenges in dogs are usually treated with a combination of training, changes to the dog’s environment, and medication or supplements.

    When To Give Your Dog Melatonin

    To address a dog’s anxiety or phobias, it may help to give a dose of melatonin prior to the trigger that can cause distress. A veterinarian may recommend providing a dose of melatonin between 30 minutes and 2 hours before the anticipated anxiety-provoking event in order to allow enough time for the supplement to take effect.

    For helping a dog sleep, avoid giving melatonin during the day. Instead, wait until around 30 minutes before the desired sleep time. To help establish healthy sleep patterns, it is recommended to give melatonin as part of a bedtime routine. Components of evening routines for dogs can include keeping a consistent bedtime, turning off bright lights, limiting noise, and providing the same comfortable place to sleep each night.

    When Should You Give Your Dog Melatonin?

    If you’re going to use melatonin to help your dog relax before bed or feel less anxiety before a procedure, administer the appropriate dose approximately two hours before bedtime or veterinary appointment. This time frame allows for the melatonin to be absorbed into your dog’s body for maximum effectiveness by the desired time. Thanks for the feedback – were glad you found our work instructive!

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    How much melatonin is safe for a dog?

    Austin is a professional writer and researcher who has covered sleep science and sleep products for over a decade.

  • Bunford, N., Reicher, V., Kis, A., Pogány, Á., Gombos, F., Bódizs, R., & Gácsi, M. (2018). Differences in pre-sleep activity and sleep location are associated with variability in daytime/nighttime sleep electrophysiology in the domestic dog. Scientific Reports, 8(1), 7109. https://pubmed.ncbi.nlm.nih.gov/29740040/
  • Kinsman, R., Owczarczak-Garstecka, S., Casey, R., Knowles, T., Tasker, S., Woodward, J., Da Costa, R., & Murray, J. (2020). Sleep duration and behaviours: A descriptive analysis of a cohort of dogs up to 12 months of age. Animals: An Open Access Journal from MDPI, 10(7), 1172. https://pubmed.ncbi.nlm.nih.gov/32664232/
  • Woods, H. J., Li, M. F., Patel, U. A., Lascelles, B., Samson, D. R., & Gruen, M. E. (2020). A functional linear modeling approach to sleep-wake cycles in dogs. Scientific Reports, 10(1), 22233. https://pubmed.ncbi.nlm.nih.gov/33335259/
  • Zisapel, N. (2018). New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. British Journal of Pharmacology, 175(16), 3190–3199. https://pubmed.ncbi.nlm.nih.gov/29318587/
  • Hansen, M. V., Halladin, N. L., Rosenberg, J., Gögenur, I., & Møller, A. M. (2015). Melatonin for pre- and postoperative anxiety in adults. The Cochrane Database of Systematic Reviews, 2015(4), CD009861. https://pubmed.ncbi.nlm.nih.gov/25856551/
  • Savage, R. A., Zafar, N., Yohannan, S., & Miller, J. (2020). Melatonin. In StatPearls. StatPearls Publishing. https://pubmed.ncbi.nlm.nih.gov/30521244/
  • Niggemann, J. R., Tichy, A., Eberspächer-Schweda, M. C., & Eberspächer-Schweda, E. (2019). Preoperative calming effect of melatonin and its influence on propofol dose for anesthesia induction in healthy dogs. Veterinary Anaesthesia and Analgesia, 46(5), 560–567. https://pubmed.ncbi.nlm.nih.gov/31351807/
  • Mogheiseh, A., Koohi, F., Nazifi, S., Shojaee Tabrizi, A., Taheri, P., & Salavati, S. (2019). Oxidative-antioxidative status and hepatic and renal factors following melatonin administration in castrated and intact dogs. Basic and Clinical Andrology, 29, 14. https://pubmed.ncbi.nlm.nih.gov/31788315/
  • Taheri, P., Mogheiseh, A., Shojaee Tabrizi, A., Nazifi, S., Salavati, S., & Koohi, F. (2019). Changes in thyroid hormones, leptin, ghrelin and, galanin following oral melatonin administration in intact and castrated dogs: a preliminary study. BMC Veterinary Research, 15(1), 145. https://pubmed.ncbi.nlm.nih.gov/31088464/
  • American Society for the Prevention of Cruelty to Animals (ASPCA). (2019, January 29). Rest easy: Getting the facts on pet safety and sleep aids., Retrieved on April 30, 2021, from https://www.aspca.org/news/rest-easy-getting-facts-pet-safety-and-sleep-aids
  • Whelan, M. (2017, September 14). Melatonin for primary immune-mediated thrombocytopenia (ITP). MSPCA-Angell., Retrieved on April 30, 2021, from https://www.mspca.org/angell_services/melatonin-for-primary-immune-mediated-thrombocytopenia-itp/
  • Plumb, D. C. (2011). Plumb’s Veterinary Drug Handbook 7th edition., Retrieved on May 1, 2021, from https://books-library.net/files/download-pdf-ebooks.org-kupd-190.pdf
  • Cummings, K. (2017, September 14). Pre-hospital sedation options for aggressive and anxious dogs. MSPCA-Angell., Retrieved May 1, 2021, from https://www.mspca.org/angell_services/pre-hospital-sedation-options-for-aggressive-and-anxious-dogs/
  • Is human melatonin safe for dogs?